Study on the Anti-inflammatory and Anti-itch Effects of Meilianjing Gel

doi:10. 3969 / j. issn. 2096-2266. 2020. 02. 009

Journal of Dali University ›› 2020, Vol. 5 ›› Issue (2): 38-42.DOI: 10. 3969 / j. issn. 2096-2266. 2020. 02. 009

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Study on the Anti-inflammatory and Anti-itch Effects of Meilianjing Gel

Cui Xueping ^{1, 2} , Li Guike ^{1, 2} , Zhao Jianting^{1, 2} , Jin Fanmao ^{1, 2} , Liu Heng ^{1, 2} , Wang Bin ^3*

（1. Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, Dali, Yunnan 671000, China; 2. National-Local
Joint Engineering Research Center of Entomoceutics, Dali, Yunnan 671000, China; 3. Department of Obstetrics and Gynecology,
The First Affiliated Hospital of Dali University, Dali, Yunnan 671000, China）

Received:2019-06-24 Revised:2019-10-02 Online:2020-02-15 Published:2020-02-15

Abstract

Abstract: Objective: To study the anti-inflammatory and anti-itch effects of Meilianjing gel. Methods: The anti-inflammatory
effects of Meilianjing gel were studied by xylene-induced mouse ear swelling experiment, carrageenin-induced mouse foot swelling
experiment, agar-induced granulation experiment and acetic-acid induced capillary permeability experiment. The anti-itch effect of
Meilianjing gel was studied by chloroquine induced mouse pruritus experiment. Results: High, middle and low dosage group of
Meilianjing gel could obviously inhibit the auricle swelling of mouse which was induced by xylene（P<0.05）and foot swelling of mouse
which was induced by carrageenan（P<0.05）. High and middle dosage group of Meilianjing gel could obviously promote the granuloma
production of mouse（P<0.01）. Middle dosage group of Meilianjing gel could obviously inhibit capillary permeability of mouse which
was induced by acetic acid（P<0.01）; high dosage group of Meilianjing gel could reduce the number of scratches of mouse itching
which was induced by chloroquine（P<0.05）. Conclusion: Meilianjing gel can reduce the swelling degree of mouse with ear and foot
swelling, reduce the capillary permeability of mouse, and relieve the symptoms of itching in mouse. Meilianjing gel has obvious anti-
inflammatory and anti-itch effects.

Key words: Periplaneta americana, anti-inflammatory, anti-itch, Meilianjing, gel

Cui Xueping,Li Guike,Zhao Jianting,Jin Fanmao,Liu Heng,Wang Bin . Study on the Anti-inflammatory and Anti-itch Effects of Meilianjing Gel[J]. Journal of Dali University, 2020, 5(2): 38-42.

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Study on the Anti-inflammatory and Anti-itch Effects of Meilianjing Gel

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